Major depressive disorder affects nearly one in four teenagers. Some characteristics of this disorder include irritability, fatigue, and low self-esteem. A major concern for this group in particular is suicide, especially since suicide is the third leading cause of death amongst teenagers. With traditional antidepressants, SSRIs, taking weeks to months to be effective and with over 40% of teenagers being non-responsive to traditional treatments, ketamine therapy may be a fast-acting treatment alternative.